Cells preparing to divide. Near the end of the animation, the condensed chromosomes can be seen, jiggling around.



26 Aug

Reeves lab submits major review article

The Reeves lab has focused on quantitative and computational aspects of the Drosophila Dorsal/NF-κB network, and has published or submitted several papers on this topic since 2015. Furthermore, as a postdoc, Dr. Reeves had also published highly-cited articles on quantitative discoveries of the shape and dynamics of the Dorsal gradient. Therefore, we are pleased to have just submitted a comprehensive review article on this system, with authors Allison Schloop and Prasad Bandodkar. The article has a specific focus on the quantitative and computational aspects of the Dorsal gradient network. This work should go to press to appear in March, 2020.

19 Aug

Reeves lab posts three manuscripts to bioRχiv

The Reeves lab has posted three manuscripts to bioRχiv, the most prominent preprint server for biological research. In the first manuscript, in collaboration with Dr. Chase Beisel's lab and with lead author Dr. Thomas Jacobsen, we characterize the use of self-cleaving ribozymes for regulating gene expression. The work was performed in mammalian cells and Drosophila embryos, demonstrating the versatility of this gene regulation tool in multiple organisms. Read more here.

In the second manuscript, we describe in detail the mechanism and phenotypes of facilitated diffusion (or shuttling) of Dorsal by Cactus in the early Drosophila embryo. This is a diffusion mechanism we have published previously, showing that, counterintuitively, it causes Dorsal to accumulate on one side of the embryo. Furthermore, we suspect it is necessary to achieve the peak levels of Dorsal signaling in the embryo. In the new manuscript, we also show that it is important for cross-talk with the BMP pathway. Read more here.

In the third study, we show that the Dorsal gradient is robust to changes in the initial amount of Dorsal in the embryo. Furthermore, we show that both shuttling (referred to above) and the presence of the inhibitor Cactus in the nucleus (see also our previous work here), are required for this robustness. Read more here.

21 Jun

Dr. Reeves publishes in JBE

Dr. Reeves had a paper published in the "Emerging leaders in biological engineering" thematic series of the Journal of Biological Engineering. Gene regulation is paramount in all aspects of biology, and one of the main motifs in gene regulation is the feedforward loop. Inspired by engineering principles found in man-made systems, Dr. Reeves shows that feedforward control in biology can be aided by adding feedback control to the gene regulation. He also shows that genetic feedback loops are present in E. coli, which was previously unreported.Read more here.

10 Jun

Reeves lab secures NSF funding

Dr. Reeves has received funding from the NSF to begin quantitative and computational work on the Dorsal/NF-κB signaling network in the Drosophila embryo. One of the paradoxes of "systems biology" is that mathematical models are needed to help interpret data on such a large scale, yet the models themselves are so large that many their unknowns hinder interpretation. The project will break down the individual processes in the system to focus on them individually. Once those are well-understood, the full system can be elucidated. Read more here.

13 May

Thomas Jacobsen earns his Ph.D!

Tom Jacobsen, co-advised by Dr. Reeves and Dr. Chase Beisel (Helmholts Inst.) successfully defended his Ph.D. work today. His projects focused on methods of gene regulation using CRISPR and self-cleaving ribozymes. He has been an invaluable member of the Reeves lab in both his mentoring of younger graduate students and undergraduates, as well as providing research expertise to aid in compile multiple manuscripts as contributing author. Congratulations Tom!


25 Jul

Hadeel Al Asafen wins image contest!

Graduate student Hadeel Al Asafen has won first place in the NCSU 2018 Envisioning Research contest in the student/postdoc category. Her video can be seen on youtube here. It depicts the dynamics Dorsal gradient when the nuclei are dividing multiple times. Read more about the contest here.

1 Jul

Allison Schloop joins the lab!

We are pleased to announce that a new student from the Genetics Program, Allison Schloop, has joined the lab. Allison earned a bachelor's degree in Biochemistry (and a minor in math) from St. Lawrence University. She will be working on the role of feedforward and feedback loops in the Dorsal gradient system.

11 May

Reeveslab has posted two new manuscripts on bioRχiv

Two recent studies performed in the lab have now been uploaded to the biology preprint server, bioRχiv. In the first study, we have used a panel of wild-caught, naturally-varying fly lines to infer relationships between proteins that act very early in embryo development. Read more here.

In the second study, we have used advanced, quantitative imaging methods to measure how proteins move in the early Drosophila embryo. Understanding protein movement is a major piece in understanding how tissues develop. Read more here.

4 May

Reeveslab welcomes four new members!

This semester, we are pleased to welcome Etika Goyal, Christopher McCallough, Prasad Bandodkar, and Lossie Rooney to the lab. Etika and Christopher are postdocs from Vellore Institute of Technology and University of Illinois at Chicago, respectively. Prasad is most recently from IIT, Delhi (Master's degree), and Lossie recently became a PhD student after studying here at NCSU. See here for more on Reeveslab members.


17 Dec

Reeveslab's fly embryo image featured on BPoD

Biomedical Picture of the Day has featured an image of early fruit fly embryos from our recent work. The image contains two embryos: the one on the left is 1-1.5 hrs younger than the one on the right. During that time span, the transcription factor Dorsal diffuses through the embyro to accumulate on the ventral side. Read more here. Image credit: Sophie Carrell.

13 Dec

NSF highlights our recent work

Our NSF-funded research, which was recently published in Development, has been highlighted on the NSF website. See also our blog post regarding the work.

16 Nov

Our recent publication in the news

Our manuscript recently accepted in Development has been highlighted in a recent news release from NC State. The title of the news article is "Researchers Find Diffusion Plays Unusual Signaling Role in Drosophila Embryos," and can be found here. (It has also been re-posted on various news outlets, such as here and here.)

06 Nov

ReevesLab is looking for one postdoc

Dr Reeves is looking for one postdoc to join the lab. The project will focus on studying the subtle changes in tissue patterning among a panel of naturally-varying fly lines. These lines have subtle genomic differences, which can be correlated to the changes in gene expression pattern. For more information, see the job posting here.

UPDATE: this project has been filled. Reeveslab is no longer looking for postdocs.

23 Oct

Manuscript accepted in Development!

Our study on the mechanism of Dorsal gradient formation has recently been accepted for publication at Development. The study was led by co-first authors Sophie Carrel and Mike O'Connell, and assisted by current student Tom Jacobsen, and two former undergraduate researchers Amy Pomeroy (Allen) and Stephanie Hayes (Smith).

31 Aug

ReevesLab is looking for two postdocs

Dr Reeves is looking for two postdocs to join the lab on two different projects. The first project will focus on the design of synthetic genetic network motifs in the early fruit fly embryo.

The second project will focus on studying the subtle changes in tissue patterning among a panel of naturally-varying fly lines. These lines have subtle genomic differences, which can be correlated to the changes in gene expression pattern. This job posting will open soon, so check back for details.

UPDATE: the first project has been filled, and the second project is open.

25 Aug

Dr Reeves receives NIH funding with Drs Rao and Williams

Dr Reeves has received funding from the NIH to begin work on two new projects. In the first, Dr Reeves and Dr Balaji Rao will collaborate to engineer novel sensors to detect RNA and short-lifetime proteins in living tissues. They will use the new technology to study the dynamics of regulatory loops in live tissues and cells.

In the second project, Dr Reeves and Dr Cranos Williams will collaborate to study regulation of signals and decision-making in developing tissues using natural variation. The lab of Dr Trudy Mackay will contrbute fly lines and expertise to the project.

11 Aug

Dr Reeves and Dr Hrischuk publish a second review paper

In the paper, Drs Reeves and Hrischuk review published "standard engineering principles" and find that the cell embodies each of these principles (save one). Additionally, they publish a novel list of Chemical Process Control Engineering Principles, and find the cell embodies these as well. The implication is there could be benefits from studying biology from an engineering point of view.


23 Sep

Sophie Carrell earns PhD

Today Sophie has defended her doctoral dissertation! Sophie has published a paper on the microscopy of embryo cross sections, and has another paper on the formation of the Dorsal gradient under revision (see here). She also initiated other projects, including how the relative dosages of Dorsal and Cactus affect patterning and how the Dorsal pathway interacts with the Dpp pathway. Congratulations Dr Carrell!

19 Aug

Ashley Jermusyk publishes paper on synthetic network

Former PhD student and recent graduate Ashley Jermusyk (now a postdoc at the NCI) just had her paper accepted for publication in BMC Systems Biology. She created, analyzed, and refined a synthetic negative feedback loop in the early Drosophila melanogaster embryo. Read more here. Congratulations Ashley!

25 Feb

Ashley Jermusyk earns PhD

Ashley has successfully defended her PhD work! In her time in my lab, she worked on several different projects, including a synthetic negative feedback loop, natural variation of gene expression patterns, and ribozyme-mediated control of gene expression. Congratulations Dr Jermusyk!

29 Jan

Sophie Carrell wins 3rd place at the Schoenborn Symposium

Sophie has won the third place prize at the Schoenborn Symposium for her talk on the formation of the Dorsal gradient in the early Drosophila embryo. The Schoenborn Symposium is an annual research symposium showcasing the body of graduate research in the Department of Chemical and Biomolecular Engineering here at NC State. Congratulations Sophie!

19 Jan

Dr. Reeves and Dr. Curtis Hrischuk publish review paper

Dr. Reeves has published a a review paper in the Computational Biology Journal on the relationship between the fields of systems engineering and systems biology. The crucial observation is that cells constitute embedded computing systems. Check it out!


15 Sep

Ashley Jermusyk publishes chapter on transcription factor networks

Ashley has published a review chapter in the Encyclopedia of Cell Biology. Congratulations Ashley!

20 Aug

Thomas Jacobsen awarded GAANN Fellowship

Tom, a graduate student co-advised by Dr. Beisel and Dr. Reeves, has been awarded a fellowship sponsored by the Graduate Assistance in Areas of National Need (GAANN) program in the area of Biotechnology. Congratulations Tom!

16 Apr

Michael O'Connell publishes paper on the Dorsal gradient

Mike has published a modeling paper in the journal PLoS Computational Biology. His work potentially reveals new roles for Dorsal's inhibitor, Cactus. Congratulations Mike!


10 Oct

Sophie Carrell publishes paper on embryo imaging

Sophie has published a methods protocol in the journal Methods in Molecular Biology. She has refined a method for manual dissection of fixed Drosophila embryos, as well as a method for upright imaging of live embryos. Congratulations Sophie!

16 Apr

Reeves and Sozzani awarded RISF funding

Dr. Reeves and Dr. Rosangela Sozzani (Plant Biology) have been awarded funding through NC State's "Research and Innovation Seed Funding" program. During the next year, they will work on acquiring data on distribution and mobility of signaling molecules in the early Drosophila embryo.

11 Apr

Dr. Reeves and Dr. Beisel awarded NSF funding

Dr. Reeves and colleague Dr. Chase Beisel (also in CBE) receive NSF funding to build and tune synthetic circuits in early Drosophila embryos. Read more here.


22 Jul

Michael O'Connell awarded GAANN Fellowship

Mike O'Connell, a graduate student in the Reeves lab, has been awarded a fellowship sponsored by the Graduate Assistance in Areas of National Need (GAANN) program in the area of Scientific Computing. Congratulations Mike!

19 May

Reeves and Deiters awarded RISF funding

Dr. Reeves and Dr. Alexander Deiters (Chemistry) have been awarded funding through NC State's "Research and Innovation Seed Funding" program. During the next year, they will work on acquiring data on regulation of gene expression in the early Drosophila embryo.

18 Mar

Dr Reeves receives NSF CAREER Award

Dr Reeves has been selected to receive the Faculty Early Career Development (CAREER) Award from the National Science Foundation. From the NSF webpage: This is one of "the National Science Foundation's most prestigious awards in support of junior faculty who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations. Such activities should build a firm foundation for a lifetime of leadership in integrating education and research." Read more here.

Prior to 2013

7 Jun

Dr Reeves' fly embryo image featured on BPoD

Biomedical Picture of the Day has featured an image of an early fruit fly embryo taken by Dr Reeves. This cross section of a 2.5 hr old embryo reveals the expression of five different genes in a spatial pattern. Read more here.

1 Aug

Dr Reeves selected as NCSU nominee for Pew Award

The Pew Scholars program grants 4-year awards to young professors in the biomedical sciences. Each school that participates in the competition can nominate one individual. In this round of competition, 22 Pew Scholars will be named.

16 Aug

Job posting for undergraduate research

I am currently looking for an undergraduate researcher to help set up my lab and continue working through the Spring 2011 and perhaps into the next year.

9 Jan

Start date for Dr Reeves changed to August 2010

I spoke with the department and together we decided to push my start date back to August of 2010. I will then be recruiting students and/or postdocs to begin that fall semester.