Hung-Jen Wu Research Lab

Chemical Engineering, Texas A&M University

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1. Multivalent lectin binding & bacterial adhesion to host cell membranes

1.    Choi H.-K., Lee D., Singla A., Kwon, J.S., Wu, H.-J., "The influence of hetero-multivalency on lectin-glycan binding behavior", Glycobiology, 29,397-408 (2019). DOI: 10.1093/glycob/cwz010

2.    Worstell, N.C., Singla, A., Wu, H. J., “Evaluation of Hetero-multivalent Lectin Binding Using a Turbidity-based Emulsion Agglutination Assay”, Colloids and Surfaces B: Biointerfaces, 175,84-90 (2019). DOI: 10.1016/j.colsurfb.2018.11.069

3.    Lee D., Mohr, A., Kwon, J. S., Wu, H. J., “Kinetic Monte Carlo modeling of multivalent binding of CTB proteins with GM1 receptors”, Computers and Chemical Engineering, in press (2018). DOI: 10.1016/j.compchemeng.2018.08.011

4.    Lee, D., Singla, A., Wu, H. J., and Kwon, J. S., “An Integrated Numerical and Experimental Framework for Modeling of CTB and GD1b Ganglioside Binding Kinetics”, AIChE Journal, in press (2018). DOI: 10.1002/aic.16209

5.    Worstell, N.C., Singla, A., Saenkham, P., Galbadage, T., Sule, P., Lee, D., Mohr, A., Kwon, J.S., Cirillo, J.D., and Wu, H.-J., “Hetero-Multivalency of Pseudomonas aeruginosa Lectin LecA Binding to Model Membranes”, Scientific Reports, 8, 8419  (2018). DOI: 10.1038/s41598-018-26643-7

6.    Krishnan, P., Singla, A., Lee, C.-A, Weatherston, J.D., Worstell, N.C., and Wu, H.-J., "Hetero-multivalent binding of Cholera Toxin Subunit B with glycolipid mixtures", Colloids and Surfaces B: Biointerfaces, vol. 160, 281-288 (2017) DOI: 10.1016/j.colsurfb.2017.09.035 [Cover Article]

7.    Worstell, N.C., Krishnan, P., Weatherston, J.D., Wu, H. -J., “Binding Cooperativity Matters: A GM1-like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array,” PLOS ONE , 11(4): e0153265 (2016)