Phanourios Tamamis Lab Texas A&M University Computational Study and Design of Biomolecular
and Material Systems |
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Research Our Approach, Goals and Research Problems of
Interest Computational methods, including molecular dynamics (MD)
simulations and free energy calculations, are increasingly becoming powerful tools
in the study and design of biomolecular and material systems. Despite the
continuous advancement of experimental methods, computational tools have
proved to be of utmost importance to fill crucial “gaps”, obtain information
that is not accessible from experiments, solve critical problems in biology,
health, and the environments, and can also leading to novel advanced
materials and therapeutics. Our lab uncovers or modulates biological interactions, designs
novel peptide-materials and clay-materials, and investigates biological
self-assembly, through the use of simulations, and the
development of novel computational tools combining structure and energetic
analysis, as well as optimization or virtual screening-based principles. |
Phanourios Tamamis Associate Professor Artie McFerrin
Department of Chemical Engineering Department of
Materials Science and Engineering (Affiliated Faculty) Texas A&M
University Lab Office: 330 GERB, Teaching Office: 225 JEB 3122 TAMU, College Station, TX 77843 Phone: 979-862-1610 Fax: 979-845-6446 |
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Our research currently focuses on
the following four areas: • Computational
design of functional peptide- and protein-based materials with applications
in biomedicine and the environment. Peptide-fibril forming
biological materials are highly promising materials for several reasons, including
their ease of fabrication and potential biocompatibility. Yet, their
functionalization to bind to single ions and compounds (e.g., to serve as
sorbents or drug carriers) relied on trial-and-error approaches and remained
a highly challenging problem. Our lab has been developing novel tools for the
simulation-based design of novel peptide nanomaterials. Our research is
primarily aiming to develop novel biological and bioinspired materials for
tissue-engineering and drug-carrier applications. • Study of
interactions between clay-based materials and toxic compounds. Clays can bind tightly various toxic chemicals
within their interlayers, and were shown to be safe for short-term human and
animal consumption. Our lab uses simulations and has been developing novel
computational tools to study the structure and dynamics of toxic compounds
binding to clays. In addition, our research is primarily aiming to develop novel
advanced clay-based materials with improved sorption properties for
particular toxic compounds.
• Study of
interactions between proteins with modified RNAs, DNAs or small compounds. Computational methods
are becoming increasingly powerful tools in delineating biomolecular
interactions owing to the difficulties associated with using experimental
techniques for solving particular problems. One such problem our lab has been
investigating involves understanding interactions between RNA and DNA
modifications with proteins, which play a vital role in biology, health and
diseases. A second problem our lab has been investigating involves the use of
docking refinement methods to predict high-accuracy compound-protein
structures. We have been developing a novel computational docking-refinement
protocol, which nearly exhaustively searches a compound’s binding site using
a suite of physics-based innovative features. • Study of amyloid
formation and inhibition as a potential therapeutic avenue for
neurodegenerative diseases. Protein aggregation and amyloid
self-assembly occurs in many diseases, including Alzheimer’s, Parkinson’s and
diabetes type 2. Tamamis lab has been
investigating the fundamentals of amyloid formation and inhibition, and is
also aiming to design novel inhibitors. Phanourios Tamamis -
Bio
Phanourios Tamamis received his B.S. degree in
2006 (excellent; top academic performance) and Ph.D. degree in 2010 from the Physics
Department of the University of Cyprus, and was recognized as the top Cypriot
undergraduate researcher in 2006. During his undergraduate,
graduate and early-postdoctoral studies, he was supervised by Professor
Georgios Archontis. After finishing his Ph.D. studies, from 2010 until 2012, Phanourios
Tamamis served as a Postdoctoral Fellow at the University of Cyprus, and as a
Short-term Fulbright scholar at the University of California at Riverside and
Princeton University, under the co-supervision of Professors Dimitrios Morikis and Christodoulos
A. Floudas. He was recognized as an “Outstanding Young Researcher” in the
2012 Computational Biophysics to Systems Biology conference. In 2013, he
joined the lab of Professor Christodoulos A.
Floudas at the Chemical and Biological Engineering Department of Princeton
University as a Postdoctoral Research Associate. In 2015, he joined Texas
A&M University as a faculty. He is currently an Associate Professor at
the Artie McFerrin Department of Chemical Engineering and an affiliated
faculty at the Department of Materials Science and Engineering. Tamamis’ lab
addresses key problems at the intersection of computational biophysics,
physical chemistry and biomolecular engineering. Among other, Tamamis’ lab
has been developing pioneering tools enabling the study of modified RNAs and
DNAs with proteins, facilitating the use of computers to functionalize-peptide
materials as tissue engineering agents or drug nanocarriers, investigation
amyloid inhibition, and enlightening how clays can be used and be improved to
be applied sorbents mitigating toxic compounds’ exposure. He received awards
for both his research and teaching. Tamamis’ lab research is currently
supported by the NSF and the NIH.
Announcements and News
Announcements Please contact us if you are interested in joining
Tamamis’ lab as a graduate or an undergraduate student. Lab Members
Patents
Compstatin
analogs, US Patent 9, 512, 180, 2016.
Amyloid
peptide scaffolds coordinate with alzheimer's
disease drugs. US Patent 62, 757, 384, 2018. Publications
Peer-Reviewed Papers and Book Chapters
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Funding
Tamamis lab has received support from: - the National Institutes for Health, Ø
National Institute on Aging Computational
Design of Novel β-wrapins
Targeting and Sequestering Amyloid-β, α-synuclein
and IAPP Ø
National Institute of Environmental
Health Sciences - the National Science Foundation Ø
NSF-BSF:
Computational and Experimental Design of Novel Peptide Nanocarriers for
Cancer Drugs |
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In addition, Tamamis lab has received
support (startup funding, seed funding and T3 funding) from Texas A&M
University andTexas A&M engineering experiment
station. Resources
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